WebMultiple testing procedures defined by directed, weighted graphs have recently been proposed as an intuitive visual tool for constructing multiple testing strategies that reflect the often complex contextual relations between hypotheses in clinical trials. ... Keywords: adaptive design; graphical approach; multiple comparisons; multiple ... WebWe consider the general situation of testing multiple hypotheses repeatedly in time using recently developed graphical approaches. We focus on closed testing procedures using …
gMCP - an R package for a graphical approach to …
WebBurman (2009) proposed graphical approach around 2009. This approach is becoming more and more popular because the complex multiplicity controlled analyses can be … WebNov 17, 2014 · Let's start with a well-known procedure and see how it ts into this graphical approach to weighted multiple test procedures: The Bonferroni-Holm-Procedure from Holm [1979]. Theorem 1.1 (Bonferroni-Holm-Procedure) . Let T ... In the rst step a graph that describes the multiple test procedures must be created. H11 1 3 H21 1 3 H31 1 3 H12 0 … soham house newmarket
Multiple Testing in Group Sequential Trials Using Graphical …
WebThe graphical approach of Bretz et al (2009) is a flexible and easily communicable way of controlling the FWER while respecting complex trial objectives and multiple structured hypotheses. However, the FWER can be a very stringent criterion that leads to procedures with low power, and may not be appropriate in exploratory trial settings. WebDec 2, 2008 · We propose a simple iterative graphical approach to construct and perform such Bonferroni-type tests. The resulting multiple test procedures are represented by directed, weighted graphs, where each node corresponds to an elementary hypothesis, together with a simple algorithm to generate such graphs while sequentially testing the … WebLarge-scale multiple testing tasks often exhibit dependence. Leveraging the dependence between individual tests is still one challenging and important problem in statistics. With recent advances in graphical models, it is feasible to use them to capture the dependence among multiple hypotheses. We propose a multiple testing procedure which is based … soham house prices