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Webb25 jan. 2024 · In cells with wild-type KRAS, we observed complete inhibition of the RAS-RAF-MEK-ERK pathway. In a mutant KRAS cell line, SOS1 inhibition resulted in a reduction of phospho-ERK activity by 50%. ... (Fig. 4A) suggested that hybrid compounds generated by linking the quinazoline inhibitor series to F1 may show increased potency. WebbTHE JOURNAL OF BIOLOGICAL CHEMISTRY 0 1989 by The American Society for Biochemistry and Molecular Biology, Inc. Vol. 264, No. 3, Isaue of January 25, pp. 1361-1367,1989 Printed in U.S.A. Inhibition of Mitochondrial F1-ATPase Activity by an Anti-a Subunit Monoclonal Antibody Which Modifies Interactions between Catalytic Webb30 dec. 2013 · To examine the therapeutic effects and underlying mechanisms of DZ2002, a reversible S-adenosyl-L-homocysteine hydrolase (SAHH) inhibitor, on lupus-prone female NZB×NZW F1 (NZB/W F1) mice. Methods Female NZB/W F1 mice were treated orally with DZ2002 (0.5 mg·kg(-1)·d(-1)) for 11 weeks, and the proteinuria level and … trach capping trial