Phosphorylation of irf3 antibody

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August undefined, 2024

WebKey features and details Rabbit polyclonal to IRF3 (phospho S396) Suitable for: WB Reacts with: Human Isotype: IgG You may also be interested in Primary Anti-IRF3 (phospho S386) antibody [EPR2346] - BSA and Azide free (ab182859) Protein Recombinant Human IRF3 protein (ab205216) Secondary Goat Anti-Rabbit IgG H&L (HRP) (ab205718) Web功能: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL.

Phosphorylation of innate immune adaptor proteins MAVS, STING, and …

WebJan 29, 2015 · Phosphorylated MAVS and STING then bind to a positively charged surface of interferon regulatory factor 3 (IRF3) and thereby recruit IRF3 for its phosphorylation and activation by TBK1. We... WebDeficiency of STING prevented IRF3 phosphorylation by ethanol or ER stress, and absence of IRF3 prevented hepatocyte apoptosis. The pathogenic role of IRF3 in ALD was independent of inflammation or Type-I interferons. Thus, STING and IRF3 are key determinants of ALD, linking ER stress signaling with the mitochondrial pathway of … flowers that animals will not eat

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WebJan 29, 2015 · Point mutations at IRF3’s positively charged surfaces abrogated IRF3 binding to MAVS and STING and subsequent IRF3 phosphorylation and activation. We … WebFigure Legend Snippet: Suppressed DOX-induced phosphorylation of IRF3, TBK1 and p65 was observed by immunoblot analysis following STING knockdown in HL-1 cells following DOX treatment (1 μm for 24 h). Quantitative data represent the relative ratio to total IRF3, TBK1 or p65 ( n = 6) Techniques Used: Western Blot Web(C–F) Western blots of phosphorylated IRF3 and beta actin in HEK293-Null and HEK293-TLR3 cells at various time points following WNV infection or post-treatment with the TLR3 agonist poly I:C. Mock infected cells and cells treated with inactivated WNV are … green box computing bv

Hsp90 Regulates Activation of Interferon Regulatory Factor 3 and …

Phospho-IRF-3 (Ser396) Antibody Cell Signaling …

WebPhospho-IRF-3 (Ser396) Antibody detects endogenous levels of IRF-3 only when phosphorylated at Ser396. This antibody does not cross-react with other family members at physiological conditions. Species Reactivity: Human. Species predicted to react based on … Highly specific and rigorously validated in-house, Phospho-IRF-3 (Ser396) (4D4G) … WebPhosphorylation of IRF3 occurs at a cluster of serine and threonine residues in the carboxy-terminus between residues 385 and 405. This leads to an association with the p300/CBP coactivator and stimulation of … flowers thanksgiving deliveryWebWestern blot analysis of Phospho-IRF3 pSer385 using Phospho-IRF3 pSer385 polyclonal antibody (Product # PA5-36775) at a dilution of 1:500. Lane 1: Hela cell lysate treated with PMA (100nM, 15min), Lane 2: … flowers that ants open

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Phosphorylation of irf3 antibody

WebControl of IRF-3 activation by phosphorylation Interferon (IFN) regulatory factor-3 (IRF-3) is a unique member of the IRF family. Its transcriptional activity is regulated solely by …

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WebJan 20, 2009 · In this study, we show that another kinase, c-Jun-NH2-terminal kinase (JNK), phosphorylates IRF3 on its N-terminal serine 173 residue, and TAK1 can stimulate IRF3 … WebAnti-IRF3 antibody [IRF35I218] (ab50772) Datasheet Reviews ( 3) Q&A (4) References (9) Key features and details Mouse monoclonal [IRF35I218] to IRF3 Suitable for: ICC/IF, WB, Flow Cyt Reacts with: Human Isotype: IgG1 You may also be interested in Primary Alexa Fluor® 488 Anti-PSMA antibody [GCP05] (ab187570)

WebMar 23, 2001 · Although the broad-spectrum kinase inhibitor staurosporine potently blocked IRF3 and -7 phosphorylation, inhibitors for protein kinase C, protein kinase A, MEK, SAPK, … WebJan 4, 2006 · The protein kinase TBK1 is a key regulator inducing phosphorylation of IRF3. The regulatory mechanisms during IRF3 activation remain poorly characterized. In the present study, we have identified by yeast two-hybrid approach a specific interaction between IRF3 and chaperone heat-shock protein of 90 kDa (Hsp90).

WebMAP3K8 mediates the phosphorylation and repression of IRF3 homodimers to promote greater transcriptional activity through utilization ... More The induction of the intrinsic antiviral defense in mammals relies on the accumulation of foreign genetic material. WebWith chromatin immunoprecipitation assays, we have now investigated whether histone methylation and phosphorylation are also involved in transcriptional regulation by thyroid hormone receptor (TR). We found that repression by unliganded TR is associated with a substantial increase in methylation of H3 lysine 9 (H3-K9) and a decrease in ...

WebMar 27, 2024 · Epac2 was detected using a rabbit polyclonal anti-Epac2 antibody (1:1000; Proteintech 19,103-1-AP). PKA subunits (RI, RIIα and Cα) were detected using mouse antibodies (1:500; BD Biosciences). ... The rate of PLB phosphorylation may be the result of a balance between an upregulation in the kinase activity, which has been reported in DCM ...

WebJan 24, 2016 · The IRF3 transcription factor is critical for the first line of defense against pathogens mainly through interferon β and antiviral gene expression. A detailed analysis … flowers that are 5 lettersWebUse Anti-phospho-IRF-3 (Ser396) Antibody (Rabbit Polyclonal Antibody) validated in WB to detect phospho-IRF-3 (Ser396) also known as Interferon regulatory factor 3. Anti-phospho … greenbox computer inkWebProtein Mutation Frequency in Cancer. The 'lollipop plot' above illustrates recurrent (observed in 3 or more out of 4440 TCGA tumor samples from 15 cancer types) and … flowers that are also colorsWebOverview Product name Anti-IRF3 (phospho S396) antibody See all IRF3 primary antibodies Description Rabbit polyclonal to IRF3 (phospho S396) Host species Rabbit Tested … flowers that ants hateWebSep 25, 2015 · Viral infection activates the transcription factors NF-κB and IRF3, which contribute to the induction of type I interferons (IFNs) and cellular antiviral responses. Protein kinases play a critical role in various signaling pathways by … green box compost madisonWebMar 21, 2024 · IRF3 (Interferon Regulatory Factor 3) is a Protein Coding gene. Diseases associated with IRF3 include Encephalopathy, Acute, Infection-Induced 7 and … greenbox compostWebPhospho-IRF3 (Ser386) Antibody (PA5-78025) in WB Western Blot using Phospho-IRF3 (Ser386) Polyclonal Antibody ( Product # PA5-78025 ). Untreated (–) and treated (+) THP-1 whole cell extracts (30 µg) were separated by 10% SDS-PAGE, and the membrane was blotted with Phospho-IRF3 (Ser386) Polyclonal Antibody ( Product # PA5-78025) diluted … green box company logo